Journal article

Childhood and long-term dietary calcium intake and adult cardiovascular risk in a population with high calcium intake

Feitong Wu, Katja Pahkala, Markus Juonala, Suvi P Rovio, Matthew A Sabin, Tapani Ronnemaa, Kylie J Smith, Antti Jula, Terho Lehtimaki, Nina Hutri-Kahonen, Mika Kahonen, Tomi Laitinen, Jorma SA Viikari, Olli T Raitakari, Costan G Magnussen

CLINICAL NUTRITION | CHURCHILL LIVINGSTONE | Published : 2021

Abstract

BACKGROUND & AIMS: The influence of dietary calcium intake in childhood on adult cardiovascular health is unknown, particularly in those with long-term high intake. To examine both linear and non-linear associations of childhood and long-term (between childhood and adulthood) dietary calcium intake with adult cardiovascular risk outcomes. METHODS: A population-based prospective cohort study in Finland (n = 1029, aged 3-18 years at baseline). Dietary calcium intake was assessed in childhood (1980, baseline) and adulthood (mean of available data from 2001, 2007 and 2011). Long-term dietary calcium intake was calculated as the mean between childhood and adulthood. Outcomes were measured in 2001..

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Grants

Awarded by Academy of Finland


Awarded by Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals


Awarded by EU Horizon 2020


Awarded by European Research Council


Awarded by National Health and Medical Research Council Project Grant


Awarded by National Health and Medical Research Council Early Career Fellowship


Awarded by 2019 Australian Endeavour Research Leadership Award


Awarded by National Heart Foundation of Australia Future Leader Fellowship


Funding Acknowledgements

The Young Finns Study has been financially supported by the Academy of Finland: grants 322098, 286284,134309 (Eye) , 126925, 121584, 124282, 129378 (Salve) , 117787 (Gendi) , and 41071 (Skidi) ; the Social Insurance Institution of Finland; Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals (grant X51001) ; Juho Vainio Foundation; Paavo Nurmi Foundation; Finnish Foundation for Cardiovascular Research; Finnish Cultural Foundation; The Sigrid Juselius Foundation; Tampere Tuberculosis Foundation; Emil Aaltonen Foundation; Yrjo? Jahnsson Foundation; Signe and Ane Gyllenberg Foundation; Diabetes Research Foundation of Finnish Diabetes Association; and EU Horizon 2020 (grant 755320 for TAXINOMISIS) ; and European Research Council (grant 742927 for MULTIEPIGEN project) ; Tampere University Hospital Supporting Foundation. This study was supported by a grant from the National?Health and Medical Research Council Project Grant (APP1098369) . FW is supported by a National Health and Medical Research Council Early Career Fellowship (APP1158661) and a 2019 Australian Endeavour Research Leadership Award (ERLA_PDR_235352_2018) . KJS is supported by NHMRC Early Career Fellowship (APP1072516) . CGM was supported by a National Heart Foundation of Australia Future Leader Fellowship (100849). They did not have any role in the study concept, design, data analysis, writing of the manuscript, or submission of the manuscript for publication. The researchers are totally independent of the funders.