Dopamine, endocannabinoids and their interaction in fear extinction and negative affect in PTSD
Luke J Ney, Jane Akhurst, Raimondo Bruno, Patrick AF Laing, Allison Matthews, Kim L Felmingham
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2021
There currently exist few frameworks for common neurobiology between reexperiencing and negative cognitions and mood symptoms of PTSD. Adopting a dopaminergic framework for PTSD unites many aspects of unique symptom clusters, and this approach also links PTSD symptomology to common comorbidities with a common neurobiological deficiency. Here we review the dopamine literature and incorporate it with a growing field of research that describes both the contribution of endocannabinoids to fear extinction and PTSD, as well as the interactions between dopaminergic and endocannabinoid systems underlying this disorder. Based on current evidence, we outline an early, preliminary model that links re-e..View full abstract
Awarded by NHMRC
This work was supported by an NHMRC Program grant to KLF (APP1073041).