Severe Obstructive Sleep Apnea Is Associated with Higher Brain Amyloid Burden: A Preliminary PET Imaging Study
Melinda L Jackson, Marina Cavuoto, Rachel Schembri, Vincent Dore, Victor L Villemagne, Maree Barnes, Fergal J O'Donoghue, Christopher C Rowe, Stephen R Robinson
Journal of Alzheimer's Disease | IOS PRESS | Published : 2020
BACKGROUND: Obstructive sleep apnea (OSA) has been linked to an increase risk of dementia. Few studies have cross-sectionally examined whether clinically-confirmed OSA is associated with a higher brain amyloid burden. OBJECTIVE: The aim of this study was to compare brain amyloid burden in individuals with untreated OSA and healthy controls, and explore associations between amyloid burden and polysomnographic and subjective measures of sleep, demographics, and mood. METHODS: Thirty-four individuals with OSA (mean age 57.5±4.1 y; 19 males) and 12 controls (mean age 58.5±4.2 y; 6 males) underwent a clinical polysomnogram and a 11C-PiB positron emission tomography (PET) scan to quantify amyloid ..View full abstract
This study was funded by the Institute for Breathing and Sleep, The Brain Foundation, The Mason Foundation and an RMIT Athena Swan Award.