Journal article

Limitations to intergenerational inheritance: subchronic paternal stress preconception does not influence offspring anxiety

KA Fennell, RGG Busby, S Li, C Bodden, SJ Stanger, B Nixon, AK Short, AJ Hannan, TY Pang

Scientific Reports | NATURE RESEARCH | Published : 2020


Independent studies have observed that a paternal history of stress or trauma is associated with his children having a greater likelihood of developing psychopathologies such as anxiety disorders. This father-to-child effect is reproduced in several mouse models of stress, which have been crucial in developing a greater understanding of intergenerational epigenetic inheritance. We previously reported that treatment of C57Bl/6J male breeders with low-dose corticosterone (CORT) for 28 days prior to mating yielded increased anxiety-related behaviours in their male F1 offspring. The present study aimed to determine whether subchronic 7-day CORT treatment of male mice just prior to mating would b..

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Funding Acknowledgements

This research was supported by an NHMRC Project grant to AJH and TYP. AJH is supported by an NHMRC Principal Research Fellowship and the DHB Foundation, Equity Trustees. CB is supported by an ARC Discovery Project grant to AJH. BN is supported by an NHMRC Senior Research Fellowship. This work received support from the Victorian government through the Operational Infrastructure Scheme.