Journal article

Thrombolysis implementation intervention and clinical outcome: a secondary analysis of a cluster randomized trial

Md Golam Hasnain, Christine L Paul, John R Attia, Annika Ryan, Erin Kerr, Christopher Oldmeadow, Catherine A D'Este, Andrew Bivard, Isobel J Hubbard, Abul Hasnat Milton, Christopher R Levi

BMC Cardiovascular Disorders | BMC | Published : 2020

Abstract

BACKGROUND: Multiple studies have attempted to increase the rate of intravenous thrombolysis for ischemic stroke using interventions to promote adherence to guidelines. Still, many of them did not measure individual-level impact. This study aimed to make a posthoc comparison of the clinical outcomes of patients in the "Thrombolysis ImPlementation in Stroke (TIPS)" study, which aimed to improve rates of intravenous thrombolysis in Australia. METHODS: A posthoc analysis was conducted using individual-level patient data. Excellent (Three-month post treatment modified Rankin Score 0-2) and poor clinical outcome (Three-month post treatment modified Rankin Score 5-6) and post treatment parenchymal..

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Grants

Awarded by National Health and Medical Research Council (NHMRC)


Awarded by NHMRC Practitioner Fellowship


Funding Acknowledgements

This study was funded by the National Health and Medical Research Council (NHMRC) partnership grant (569328), part-funded by an NHMRC Practitioner Fellowship (1043913) and NHMRC Translating Research Into Practice fellowship, and included partnership grant contribution funding from Boehringer Ingelheim, in-kind support from Agency for Clinical Innovation Stroke Care Network/Stroke Services New South Wales (NSW), Stroke Foundation and NSW Cardiovascular Research Network-National Heart Foundation, with a cash contribution from the Victorian Stroke Clinical Network and infrastructure funding from the Hunter Medical Research Institute and The University of Newcastle. The funders had no input into the design, data collection, analysis, interpretation of study findings, or preparation of manuscript.