Journal article

Antidepressant Medications and Weight Change: A Narrative Review

Hartej Gill, Barjot Gill, Sabine El-Halabi, David Chen-Li, Orly Lipsitz, Joshua Daniel Rosenblat, Tamsyn E Van Rheenen, Nelson B Rodrigues, Rodrigo B Mansur, Amna Majeed, Leanna MW Lui, Flora Nasri, Yena Lee, Roger S Mcintyre

OBESITY | WILEY | Published : 2020


Antidepressant medications are the first-line treatment option for moderate to severe major depressive disorder. However, most antidepressants have numerous documented adverse events, including cardiometabolic effects and weight gain, which are major public health concerns. Antidepressant agents provide varying risk of associated weight gain, including significant within-class differences. Some agents, such as mirtazapine, show significant levels of weight gain, while others, such as bupropion, demonstrate weight-loss effects. Current findings suggest the role of histamine and serotonin off-target appetite-promoting pathways in adverse weight-gain effects. Therefore, controlling for undesire..

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University of Melbourne Researchers