Journal article

Understanding motor difficulties in children with ADHD: A fixel-based analysis of the corticospinal tract

Christian Hyde, Ian Fuelscher, Emma Sciberras, Daryl Efron, Vicki A Anderson, Tim Silk

Progress in Neuro-Psychopharmacology and Biological Psychiatry | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2021

Abstract

AIMS: Children with attention deficit hyperactivity disorder (ADHD) often present with deficits in fine motor control. The cortico-spinal tract (CST) is critical for voluntary motor control. Although neuroimaging work has identified anomalous microstructural properties in the CST in ADHD, no study to date has attempted to investigate the link between deficits in fine motor performance and microstructural properties of the CST in children with ADHD. This study aimed to address this gap using a novel fixel-based analysis (FBA). METHODS: Participants were 50 right-handed medication naïve children with a history of ADHD and 56 non-ADHD controls aged 9-11 years. Fine motor control was assessed us..

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Grants

Awarded by Australian National Health and Medical Research Council (NHRMC)


Awarded by NHMRC Career Development Fellowship


Funding Acknowledgements

This project is funded by Project Grants from the Australian National Health and Medical Research Council (NHRMC) (1065895, 1008522). A/Prof Sciberras' position is funded by an NHMRC Career Development Fellowship (1110688: 2016-21) and a Veski Inspiring Women's Fellowship. A/Prof Efron is funded by a Clinician Scientist Fellowship from the Murdoch Children's Research Institute (MCRI). This research was conducted within the Developmental Imaging research group, Murdoch Children's Research Institute and the Children's MRI Centre, The Royal Children's Hospital, and in the School of Psychology, Deakin University, Melbourne, Victoria. It was supported by the Murdoch Children's Research Institute, The Royal Children's Hospital, The Royal Children's Hospital Foundation, Department of Paediatrics at The University of Melbourne and the Victorian Government's Operational Infrastructure Support Program.