Journal article

Trace Amine-Associated Receptor 1 (TAAR1): A new drug target for psychiatry?

Seetal Dodd, André F Carvalho, Basant K Puri, Michael Maes, Chiara C Bortolasci, Gerwyn Morris, Michael Berk

Neuroscience & Biobehavioral Reviews | Published : 2020

Abstract

There are nine subfamilies of TAARs. They are predominantly intracellular, located in the central nervous system and peripherally. They have a role in homeostasis and rheostasis, and also in olfaction. They demonstrate significant cross-talk with the monoamine system and are involved in the regulation of cAMP signalling and K+ channels. There is evidence to suggest that TAAR1 may be a promising therapeutic target for the treatment of schizophrenia, psychosis in Parkinson's disease, substance use disorders, and the metabolic syndrome and obesity. TAAR1 expression may also be a prognostic biomarker for cancers. A number of TAAR modulators have been identified, including endogenous ligands and ..

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