Intracranial and subcortical volumes in adolescents with early-onset psychosis: A multisite mega-analysis from the ENIGMA consortium

TP Gurholt; V Lonning; S Nerland; KN Jørgensen; UK Haukvik; C Alloza; C Arango; C Barth; CE Bearden; M Berk; H Bohman; O Dandash; CM Díaz-Caneja; CT Edbom; TGM van Erp; AKJ Fett; S Frangou; BI Goldstein; A Grigorian; N Jahanshad; AC James; J Janssen; C Johannessen; KH Karlsgodt; MJ Kempton; P Kochunov; L Krabbendam; M Kyriakopoulos; M Lundberg; BJ MacIntosh; BR Rund; RE Smelror; A Sultan; CK Tamnes; SI Thomopoulos; A Vajdi; K Wedervang-Resell; AM Myhre; OA Andreassen; PM Thompson; I Agartz

Journal article

Intracranial and subcortical volumes in adolescents with early-onset psychosis: A multisite mega-analysis from the ENIGMA consortium

TP Gurholt, V Lonning, S Nerland, KN Jørgensen, UK Haukvik, C Alloza, C Arango, C Barth, CE Bearden, M Berk, H Bohman, O Dandash, CM Díaz-Caneja, CT Edbom, TGM van Erp, AKJ Fett, S Frangou, BI Goldstein, A Grigorian, N Jahanshad Show all

Human Brain Mapping | WILEY | Published : 2022

DOI: 10.1002/hbm.25212

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Abstract

Early-onset psychosis disorders are serious mental disorders arising before the age of 18 years. Here, we investigate the largest neuroimaging dataset, to date, of patients with early-onset psychosis and healthy controls for differences in intracranial and subcortical brain volumes. The sample included 263 patients with early-onset psychosis (mean age: 16.4 ± 1.4 years, mean illness duration: 1.5 ± 1.4 years, 39.2% female) and 359 healthy controls (mean age: 15.9 ± 1.7 years, 45.4% female) with magnetic resonance imaging data, pooled from 11 clinical cohorts. Patients were diagnosed with early-onset schizophrenia (n = 183), affective psychosis (n = 39), or other psychotic disorders (n = 41)...

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University of Melbourne Researchers

Michael Berk Author

Orwa Dandash Author

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A GLOBAL ALLIANCE TO UNLOCK BRAIN MECHANISMS INFLUENCING SUICIDAL BEHAVIORS THROUGH THE ENIGMA CONSORTIUM

ABSTRACT One million people around the world die from suicide annually. Suicide is the tenth leading cause of death for all ages and the sec..

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Awarded by Instituto de Investigación Sanitaria Gregorio Marañón

Funding Acknowledgements

Forskningsradet om Halsa, Arbetsliv och Valfard, Grant/Award Numbers: 2017-00949, 521-2014-3487; Helse Sor-Ost RHF, Grant/Award Numbers: 2004-259, 2006-186, 2017112; Horizon 2020 Framework Programme, Grant/Award Numbers: 115916, 777394; National Alliance for Research on Schizophrenia and Depression, Grant/Award Number: 24138; National Health and Medical Research Council, Grant/Award Numbers: 1059660, APP1156072; National Institutes of Health, Grant/Award Numbers: MH105808, P50MH066286, R01EB015611, R01MH101506, R01MH113619, R01MH116147, R01MH117601, S10OD023696, U54EB020403; Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Grant/Award Numbers: 451-13-035, 453-11-005; Norges Forskningsrad, Grant/Award Numbers: 2137000, 223273, 250358, 288083; Seventh Framework Programme, Grant/Award Numbers: FP7-HEALTH-2013-2.2.1-2-602478, FP7-HEALTH2009-2.2.1-2-241909, FP7-HEALTH2009-2.2.1-3-242114, FP7-HEALTH2013-2.2.1-2-603196; Stiftelsen Kristian Gerhard Jebsen, Grant/Award Number: SKGJ-MED-008; Svenska Forskningsradet Formas, Grant/Award Number: 259-2012-31