Journal article

Intracranial and subcortical volumes in adolescents withearly-onsetpsychosis: A multisitemega-analysisfrom theENIGMAconsortium

Tiril P Gurholt, Vera Lonning, Stener Nerland, Kjetil N Jorgensen, Unn K Haukvik, Clara Alloza, Celso Arango, Claudia Barth, Carrie E Bearden, Michael Berk, Hannes Bohman, Orwa Dandash, Covadonga M Diaz-Caneja, Carl T Edbom, Theo GM van Erp, Anne-Kathrin J Fett, Sophia Frangou, Benjamin I Goldstein, Anahit Grigorian, Neda Jahanshad Show all

Human Brain Mapping | WILEY | Published : 2020

Abstract

Early-onset psychosis disorders are serious mental disorders arising before the age of 18 years. Here, we investigate the largest neuroimaging dataset, to date, of patients with early-onset psychosis and healthy controls for differences in intracranial and subcortical brain volumes. The sample included 263 patients with early-onset psychosis (mean age: 16.4 ± 1.4 years, mean illness duration: 1.5 ± 1.4 years, 39.2% female) and 359 healthy controls (mean age: 15.9 ± 1.7 years, 45.4% female) with magnetic resonance imaging data, pooled from 11 clinical cohorts. Patients were diagnosed with early-onset schizophrenia (n = 183), affective psychosis (n = 39), or other psychotic disorders (n = 41)...

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University of Melbourne Researchers

Grants

Awarded by Forskningsradet om Halsa, Arbetsliv och Valfard


Awarded by Helse Sor-Ost RHF


Awarded by Horizon 2020 Framework Programme


Awarded by National Alliance for Research on Schizophrenia and Depression


Awarded by National Health and Medical Research Council


Awarded by National Institutes of Health


Awarded by Nederlandse Organisatie voor Wetenschappelijk Onderzoek


Awarded by Norges Forskningsrad


Awarded by Seventh Framework Programme


Awarded by Stiftelsen Kristian Gerhard Jebsen


Awarded by Svenska Forskningsradet Formas


Funding Acknowledgements

Forskningsradet om Halsa, Arbetsliv och Valfard, Grant/Award Numbers: 2017-00949, 521-2014-3487; Helse Sor-Ost RHF, Grant/Award Numbers: 2004-259, 2006-186, 2017112; Horizon 2020 Framework Programme, Grant/Award Numbers: 115916, 777394; National Alliance for Research on Schizophrenia and Depression, Grant/Award Number: 24138; National Health and Medical Research Council, Grant/Award Numbers: 1059660, APP1156072; National Institutes of Health, Grant/Award Numbers: MH105808, P50MH066286, R01EB015611, R01MH101506, R01MH113619, R01MH116147, R01MH117601, S10OD023696, U54EB020403; Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Grant/Award Numbers: 451-13-035, 453-11-005; Norges Forskningsrad, Grant/Award Numbers: 2137000, 223273, 250358, 288083; Seventh Framework Programme, Grant/Award Numbers: FP7-HEALTH-2013-2.2.1-2-602478, FP7-HEALTH2009-2.2.1-2-241909, FP7-HEALTH2009-2.2.1-3-242114, FP7-HEALTH2013-2.2.1-2-603196; Stiftelsen Kristian Gerhard Jebsen, Grant/Award Number: SKGJ-MED-008; Svenska Forskningsradet Formas, Grant/Award Number: 259-2012-31