Antidiabetes agents and incident depression: A nationwide population-based study

Abstract

OBJECTIVE Diabetes is associated with an increased risk of depression. Some antidiabetes agents, specifically metformin and pioglitazone, have been suggested to have beneficial effects on depression, but associations between antidiabetes drugs and depression have not been systematically investigated. RESEARCH DESIGN AND METHODS We combined four Danish population-based registers to investigate whether the 20 most widely used orally administered antidiabetes drugs were associated with an altered risk of incident depression. Analyses of insulin were included for compar-isons. All persons in Denmark in 2005 were included in the study and followed until 2015. Two different outcome measures of inc..