Antidiabetes Agents and Incident Depression: A Nationwide Population-Based Study
Lars Vedel Kessing, Helene Charlotte Rytgaard, Claus Thorn Ekstrom, Filip Krag Knop, Michael Berk, Thomas Alexander Gerds
Diabetes Care | AMER DIABETES ASSOC | Published : 2020
OBJECTIVE: Diabetes is associated with an increased risk of depression. Some antidiabetes agents, specifically metformin and pioglitazone, have been suggested to have beneficial effects on depression, but associations between antidiabetes drugs and depression have not been systematically investigated. RESEARCH DESIGN AND METHODS: We combined four Danish population-based registers to investigate whether the 20 most widely used orally administered antidiabetes drugs were associated with an altered risk of incident depression. Analyses of insulin were included for comparisons. All persons in Denmark in 2005 were included in the study and followed until 2015. Two different outcome measures of in..View full abstract
Awarded by Danish National Research Fund (Independent Research Fund Denmark)
Awarded by National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship
The study was funded by the Danish National Research Fund (Independent Research Fund Denmark) (grant number 6110-00096B). M.B. is supported by a National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship (1156072). M.B. has received grant/research support from the National Institutes of Health, Cooperative Research Centre, Simons AutismFoundation, Cancer Council of Victoria, Stanley Medical Research Foundation, Medical Benefits Fund, NHMRC, andMedical Research Futures Fund.