Journal article

Non-alcoholic fatty liver disease (NAFLD) as a neglected metabolic companion of psychiatric disorders: common pathways and future approaches

Oscar Soto-Angona, Gerard Anmella, Maria Jose Valdes-Florido, Nieves De Uribe-Viloria, Andre F Carvalho, Brenda WJH Penninx, Michael Berk

BMC Medicine | BMC | Published : 2020

Abstract

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis in over 5% of the parenchyma in the absence of excessive alcohol consumption. It is more prevalent in patients with diverse mental disorders, being part of the comorbidity driving loss of life expectancy and quality of life, yet remains a neglected entity. NAFLD can progress to non-alcoholic steatohepatitis (NASH) and increases the risk for cirrhosis and hepatic carcinoma. Both NAFLD and mental disorders share pathophysiological pathways, and also present a complex, bidirectional relationship with the metabolic syndrome (MetS) and related cardiometabolic diseases. MAIN TEXT: This review compares the d..

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University of Melbourne Researchers