Gut dysbiosis in Huntington's disease: associations among gut microbiota, cognitive performance and clinical outcomes
Cory Wasser, Emily-Clare Mercieca, Geraldine Kong, Anthony J Hannan, Sonja J McKeown, Yifat Glikmann-Johnston, Julie C Stout
BRAIN COMMUNICATIONS | OXFORD UNIV PRESS | Published : 2020
Huntington's disease is characterized by a triad of motor, cognitive and psychiatric impairments, as well as unintended weight loss. Although much of the research has focused on cognitive, motor and psychiatric symptoms, the extent of peripheral pathology and the relationship between these factors, and the core symptoms of Huntington's disease, are relatively unknown. Gut microbiota are key modulators of communication between the brain and gut, and alterations in microbiota composition (dysbiosis) can negatively affect cognition, behaviour and affective function, and may be implicated in disease progression. Furthermore, gut dysbiosis was recently reported in Huntington's disease transgenic ..View full abstract
Awarded by NHMRC-Australian Research Council Dementia Research Development Fellowship
J.S. is an Australian Government National Health and Medical Research Council (NHRMC) Leadership Fellow and A.H. is an NHMRC Principal Research Fellow. This project was partly supported by an NHMRC-Australian Research Council Dementia Research Development Fellowship (grant number 1100862) awarded to Y. G-J. We greatly appreciate further generous donations received from The Fox Family Foundation, Torquay Coasters Cycling Group, and a private donation from Tacie Fox.