A beta-accelerated neurodegeneration caused by Alzheimer's-associated ACE variant R1279Q is rescued by angiotensin system inhibition in mice
Leah K Cuddy, Dmitry Prokopenko, Eric P Cunningham, Ross Brimberry, Peter Song, Rory Kirchner, Brad A Chapman, Oliver Hofmann, Winston Hide, Daniele Procissi, Taleen Hanania, Steven C Leiser, Rudolph E Tanzi, Robert Vassar
Science Translational Medicine | AMER ASSOC ADVANCEMENT SCIENCE | Published : 2020
Awarded by Northwestern Alzheimer's Disease Center
We thank the Cure Alzheimer's Fund for generously supporting this study to R. V. and R.E.T. We also thank the American Federation for Aging Research (AFAR) for a postdoctoral fellowship award to L.K.C. We thank E. Bigio and the Northwestern Alzheimer's Disease Center (P30 AG013854 to R.V.) for fixed AD brain tissue. Frozen human frontal cortex was obtained from D. Bennett at Rush University (R01AG17917). R.K., B.A.C., O.H., and W.H. at the Harvard Chan Bioinformatics Core were supported, in part, by the Harvard NeuroDiscovery Center.