Acute neuroimmune stimulation impairs verbal memory in adults: A PET brain imaging study
Eric A Woodcock, Ansel T Hillmer, Christine M Sandiego, Paul Maruff, Richard E Carson, Kelly P Cosgrove, Robert H Pietrzak
Brain Behavior and Immunity | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2021
Psychiatric and neurologic disorders are often characterized by both neuroinflammation and cognitive dysfunction. To date, however, the relationship between neuroinflammation and cognitive dysfunction remains understudied in humans. Preclinical research indicates that experimental induction of neuroinflammation reliably impairs memory processes. In this paradigm development study, we translated those robust preclinical findings to humans using positron emission tomography (PET) imaging with [11C]PBR28, a marker of microglia, and lipopolysaccharide (LPS), a potent neuroimmune stimulus. In a sample of 18 healthy adults, we extended our previous findings that LPS administration increased whole-..View full abstract
Awarded by National Institute on Drug Abuse
Awarded by National Institute of Mental Health
This study was supported by grants from the National Institute on Drug Abuse [K02 DA031750 (KPC), K01 AA024788 (ATH), T32 DA022975 (postdoctoral fellow: EAW), and K99 DA048125 (EAW)], the National Institute of Mental Health [R01 MH110674 (KPC, RHP)] and the Clinical Neurosciences Division of the U.S. Department of Veterans Affairs National Center for Posttraumatic Stress Disorder.