Journal article

Effects of an anti-IGF-1 receptor monoclonal antibody on laminitis induced by prolonged hyperinsulinaemia in Standardbred horses

Samira Rahnama, Niveditha Vathsangam, Robert Spence, Carlos E Medina-Torres, Christopher C Pollitt, Melody A de Laat, Simon R Bailey, Martin N Sillence

PLoS One | Public Library of Science (PLoS) | Published : 2020

Abstract

Currently, there are no registered veterinary drugs for the treatment of endocrinopathic equine laminitis, and although this form of the disease is known to be caused by prolonged hyperinsulinaemia, the mechanism of insulin toxicity is unclear. One possibility is that high concentrations of insulin activate IGF-1 receptors (IGF-1R) in lamellar tissue, leading to uncontrolled cell proliferation and epidermal lamellar dysregulation. An equinized version of a human anti-IGF-1R therapeutic monoclonal antibody (mAb11) was generated to test this theory, using a modification of the prolonged euglycaemic-hyperinsulinaemic clamp technique. Healthy Standardbred horses were infused for 48 h with 0.9% s..

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University of Melbourne Researchers

Grants

Awarded by Australian Research Council (AU)


Funding Acknowledgements

This study was supported by funding from the Australian Research Council (AU) LP150101025, Zoetis, the Animal Health Foundation and Nexvet Biopharma. The funders had no role in study design, data collection and analysis, or preparation of the manuscript. Zoetis had a role in the decision to publish.