Journal article

Tunable Harmonic Flow Patterns in Microfluidic Systems through Simple Tube Oscillation

Peter Thurgood, Sergio Aguilera Suarez, Elena Pirogova, Aaron R Jex, Karlheinz Peter, Sara Baratchi, Khashayar Khoshmanesh

Small | Wiley | Published : 2020

Abstract

Generation of tunable harmonic flows at low cost in microfluidic systems is a persistent and significant obstacle to this field, substantially limiting its potential to address major scientific questions and applications. This work introduces a simple and elegant way to overcome this obstacle. Harmonic flow patterns can be generated in microfluidic structures by simply oscillating the inlet tubes. Complex rib and vortex patterns can be dynamically modulated by changing the frequency and magnitude of tube oscillation and the viscosity of liquid. Highly complex rib patterns and synchronous vortices can be generated in serially connected microfluidic chambers. Similar dynamic patterns can be ge..

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Grants

Awarded by Australian National Health and Medical Research Foundation Career Development Fellowship program


Awarded by NHMRC


Awarded by Australian Research Council (ARC)


Awarded by ARC


Funding Acknowledgements

S.B. and K.K. contributed equally to this work. The authors wish to acknowledge RMIT's MicroNano Research Facility (MNRF) for the fabrication of microfluidic devices. A.R.J. acknowledges the Australian National Health and Medical Research Foundation Career Development Fellowship program (APP1126395). A.R.J. also acknowledges funding from the Victorian State Government Operational Infrastructure Support and Australian Government National Health and Medical Research Council (NHMRC) Independent Research Institute Infrastructure Support Scheme. E.P. acknowledges NHMRC for funding "The Australian Centre for Electromagnetic Bioeffects Research" (NHMRC CRE APP1135076). K.P. acknowledges the NHMRC for the Principal Research Fellowship (GNT1079492). S.B. acknowledges the Australian Research Council (ARC) for Discovery for Discovery Grant (DE170100239 and DP200101248). A.R.J. and K.K. acknowledge ARC for Discovery Grant (DP180102049).