Journal article

Structural neuroimaging biomarkers for obsessive-compulsive disorder in the ENIGMA-OCD consortium: medication matters

Willem B Bruin, Luke Taylor, Rajat M Thomas, Jonathan P Shock, Paul Zhutovsky, Yoshinari Abe, Pino Alonso, Stephanie H Ameis, Alan Anticevic, Paul D Arnold, Francesca Assogna, Francesco Benedetti, Jan C Beucke, Premika SW Boedhoe, Irene Bollettini, Anushree Bose, Silvia Brem, Brian P Brennan, Jan K Buitelaar, Rosa Calvo Show all

Translational Psychiatry | SPRINGERNATURE | Published : 2020

Abstract

No diagnostic biomarkers are available for obsessive-compulsive disorder (OCD). Here, we aimed to identify magnetic resonance imaging (MRI) biomarkers for OCD, using 46 data sets with 2304 OCD patients and 2068 healthy controls from the ENIGMA consortium. We performed machine learning analysis of regional measures of cortical thickness, surface area and subcortical volume and tested classification performance using cross-validation. Classification performance for OCD vs. controls using the complete sample with different classifiers and cross-validation strategies was poor. When models were validated on data from other sites, model performance did not exceed chance-level. In contrast, fair cl..

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Grants

Awarded by NIH BD2K (Big Data to Knowledge) award


Awarded by Japan Society for the Promotion of Science (JSPS; KAKENHI)


Awarded by Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP, Sao Paulo Research Foundation)


Awarded by EU FP7 project TACTICS


Awarded by National Natural Science Foundation of China


Awarded by Dutch Organization for Scientific Research (NWO)


Awarded by Netherlands Society for Scientific Research (NWO-ZonMw VENI grant)


Awarded by Netherlands Society for Scientific Research (NWOZonMw AGIKO stipend)


Awarded by Netherlands Brain Foundation


Awarded by Federal Ministry of Education and Research of Germany


Awarded by Deutsche Forschungsgemeinschaft (DFG)


Awarded by Helse Vest Health Authority


Awarded by Norwegian Research Council


Awarded by South London and Maudsley Trust, London, UK


Awarded by Generalitat de Catalunya (AGAUR)


Awarded by PhDiHES program (FCT fellowship Grant)


Awarded by Japanese Ministry of Education, Culture, Sports, Science and Technology


Awarded by Italian Ministry of Health


Awarded by National Center for Advancing Translational Sciences


Awarded by Netherlands Organization for Scientific Research (NWO/ZonMW Vidi)


Awarded by Wellcome-DBT India Alliance


Awarded by Shanghai Key Laboratory of Psychotic Disorders


Awarded by Government of India grants from the Department of Science and Technology


Awarded by Government of India grants from the Department of Science and Technology (DST INSPIRE faculty grant)


Awarded by Department of Biotechnology


Awarded by NIMH


Awarded by David Judah Fund at the Massachusetts General Hospital


Awarded by Marato TV3 Foundation


Awarded by Carlos III Health Institute


Awarded by AGAUR


Awarded by Japan Agency for Medical Research and Development (AMED Brain/MINDS Beyond program Grant)


Awarded by NIH/NIDA


Awarded by Royal Society


Awarded by Jacobs Foundation


Awarded by Brain and Behavior Research Foundation (2018 NARSAD Young Investigator grant)


Awarded by Swiss National Science Foundation (SNSF)


Awarded by Harmann Muller foundation


Awarded by NHMRC Career Development Fellowship



Funding Acknowledgements

The ENIGMA-Obsessive Compulsive Disorder Working-Group gratefully acknowledges support from the NIH BD2K (Big Data to Knowledge) award U54 EB020403 (PI: Dr. Thompson) and Neuroscience Amsterdam, and an IPB grant to Dr. Schmaal and Dr. van den Heuvel. Supported by the Japan Society for the Promotion of Science (JSPS; KAKENHI Grants No. 18K15523 to Dr. Abe, No. 16K19778, No. 18K07608 to Dr. Nakamae, No. 16K04344, 19K03309 to Dr. Hirano, and No. 26461762 to Dr. Nakagawa); the Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP, Sao Paulo Research Foundation; Grant No. 2011/21357-9; 2018/04654-9 and 2018/21934-5); the EU FP7 project TACTICS (Grant No. 278948 to Dr. Buitelaar); the National Natural Science Foundation of China (No. 81560233 to Dr. Cheng); the International ObsessiveCompulsive Disorder Foundation (IOCDF) Research Award to Dr. Gruner; the Dutch Organization for Scientific Research (NWO) (grants 912-02-050, 907-00-012, 940-37-018, and 916.86.038); the Netherlands Society for Scientific Research (NWO-ZonMw VENI grant 916.86.036 to Dr. van den Heuvel; NWOZonMw AGIKO stipend 920-03-542 to Dr. de Vries), a NARSAD Young Investigator Award to Dr. van den Heuvel, and the Netherlands Brain Foundation (2010(1)-50 to Dr. van den Heuvel); the Federal Ministry of Education and Research of Germany (No. BMBF-01GW0724 to Dr. Kathmann); the Alberta Innovates Translational Health Chair in Child and Youth Mental Health and funding from the Ontario Brain Institute to Dr. Arnold; the Deutsche Forschungsgemeinschaft (DFG; Grant No. KO 3744/7-1 to Dr. Koch); the Helse Vest Health Authority (No. 911754, 911880 to Dr. Kvale) and the Norwegian Research Council (No. HELSEFORSK 243675 to Dr. Kvale); the Wellcome Trust and a pump priming grant from the South London and Maudsley Trust, London, UK (Project Grant No. 064846 to Dr. Mataix-Cols); the Generalitat de Catalunya (AGAUR 2017 SGR 1247 to Dr. Menchon); the PhDiHES program (FCT fellowship Grant No. PDE/BDE/113601/2015 to Dr. Moreira); the Japanese Ministry of Education, Culture, Sports, Science and Technology (Grant-in-Aid for Scientific Research (C) 22591262, 25461732, 16K10253 to Dr. Nakao); the Italian Ministry of Health (No. RC13-14-15-16-17-18A to Dr. Spalletta, Dr. Piras Fabrizio, Dr. Piras Federica); the National Center for Advancing Translational Sciences (Grants No. UL1TR000067/KL2TR00069 to Dr. Stern); the SA MRC funding and the National Research Foundation of South Africa to Dr. Stein and Dr. Lochner; the Canadian Institutes of Health Research, Michael Smith Foundation for Health Research, and British Columbia Provincial Health Services Authority funding Dr. Stewart; the Netherlands Organization for Scientific Research (NWO/ZonMW Vidi 917.15.318 to Dr. van Wingen); the Wellcome-DBT India Alliance (Grant No. 500236/Z/11/Z to Dr. Venkatasubramanian); the National Natural Science Foundation of China (No. 81371340) and the Shanghai Key Laboratory of Psychotic Disorders (No. 13dz2260500) to Dr. Wang; the Government of India grants from the Department of Science and Technology (Grants No. SR/S0/HS/0016/2011 to Prof. Y.C. Janardhan Reddy, and DST INSPIRE faculty grant-IFA12-LSBM-26 to Dr. Janardhanan C. Narayanaswamy) and from the Department of Biotechnology (Grants No. BT/PR13334/Med/30/259/2009 to Prof. Y.C. Janardhan Reddy, and No. BT/06/IYBA/2012 to Dr. Janardhanan C. Narayanaswamy); the Dana Foundation and NARSAD to Dr. Fitzgerald; the NIMH (Grants No. R01 MH107419 and No. K23MH082176 to Dr. Fitzgerald, Grant No. K23MH082176 to Dr. Marsh, Grant No. R21MH093889 to Drs.Marsh and Simpson, Grant No. K23MH104515 to Dr. Baker; Grant No. R33MH107589 to Dr. Stern, Grant No. R01MH111794 to Dr. Stern; Grant No. R01 MH081864 to Drs. O'Neill and Piacentini; Grant No. R01 MH085900 to Drs. O'Neill and Feusner, Grant No. K23 MH115206 to Dr. Gruner); the NIMH and the David Judah Fund at the Massachusetts General Hospital (Grant No. K23-MH092397 to Dr. Brennan); the Marato TV3 Foundation (Grants No. 01/2010 and 091710 to Dr. Lazaro); the Carlos III Health Institute (PI040829 to Dr Lazaro, Grant CPII16/00048 and Project Grants PI13/01958 and PI16/00889 to Dr. Soriano-Mas), co-funded by FEDER funds/European Regional Development Fund (ERDF), a way to build Europe; the AGAUR (2017 SGR 881 to Dr. Lazaro); the Michael Smith Foundation for Health Research funding Dr. Jaspers-Fayer and Dr. Stewart; the Carlos III Health Institute (PI14/00419 to Dr. Alonso, Grant No. FI17/00294 to Ignacio Martinez-Zalacain, Project Grant No. PI16/00950 to Dr. Menchon); the Japan Agency for Medical Research and Development (AMED Brain/MINDS Beyond program Grant No. JP19dm0307002 to Dr. Shimizu); Oxford Health Services Research Committee grant to Dr A James and National Institute on Drug Abuse to Dr. Ivanov (NIH/NIDA Grant No. R21/DA046029 and No. R21/DA045218); the Wellcome and Royal Society (211155/Z/18/Z) to Tobias U Hauser; the Jacobs Foundation (2017-1261-04) to Tobias U Hauser, the Medical Research Foundation, and the Brain and Behavior Research Foundation (2018 NARSAD Young Investigator grant; 27023) to Tobias U. Hauser; the Swiss National Science Foundation (SNSF 320030_130237) to Susanne Walitza; the Harmann Muller foundation (1460) to Silvia Brem; NHMRC Career Development Fellowship (1140764 to Dr. Schmaal).