Journal article

Cancer and scleroderma: recent insights

Kathleen Morrisroe, Mandana Nikpour

Current Opinion in Rheumatology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2020

Abstract

Purpose of review As survival in systemic sclerosis (SSc) improves, research interest has shifted to the leading cause of non-SSc-related death, namely cancer, which accounts for over a third of non-SSc-related deaths. This review will provide an overview of the recent insights into the evolving relationship between SSc and cancer. Recent findings Recent studies confirm the increased risk of cancer in SSc compared with the general population (standardized incidence ratio 1.9–2.2) in particular the risk of breast, lung and skin cancer. This increased cancer risk, particularly occurring in close proximity to SSc onset, raises the novel concept of autoimmunity occurring as a direct immune re..

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Grants

Awarded by National Health and Medical Research Council of Australia Career Development Fellowship


Awarded by NHMRC Investigator Grant


Funding Acknowledgements

M. N. holds a National Health and Medical Research Council of Australia Career Development Fellowship (APP 1126370). K.M. holds a NHMRC Investigator Grant (APP1197169). No funding from the National Institutes of Health, Wellcome Trust or Howard Hughes Medical Institute (HHMI) were received.