When it's good to have MAITs

Michael NT Souter; James McCluskey; Alexandra J Corbett

Journal article

When it's good to have MAITs

Michael NT Souter, James McCluskey, Alexandra J Corbett

IMMUNOLOGY AND CELL BIOLOGY | WILEY | Published : 2020

DOI: 10.1111/imcb.12402

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Abstract

This article discusses mucosal-associated invariant T-cell prophylactic and therapeutic vaccination schemes tested by Sakai et al. in mouse models of Mycobacterium tuberculosis infection together with the outcomes and observations.

University of Melbourne Researchers

Alexandra Corbett Author Microbiology and Immunology

James McCluskey Author

Michael Souter Author Microbiology and Immunology

Related Projects (4)

Investigating the basis of MAIT cell antigen potency (NIH R01 Resubmission)

SUMMARY Mucosal Associated Invariant T (MAIT) cells comprise up to 10% of human peripheral blood T cells, and are enriched in the liver, lun..

A STRUCTURAL, CHEMICAL AND FUNCTIONAL INVESTIGATION INTO MAIT CELL RECEPTOR RECOGNITION

This project is focused on a type of T-cell, termed a MAIT cell, which is found abundantly in the lining of the gut. We are investigating ho..

ANTIGEN PRESENTATION, RECOGNITION AND THE IMMUNE RESPONSE

This program focuses on understanding the development of immunity during infection or inflammatory diseases using a broad array of technique..

Understanding recognition of vitamin B-based antigens by the immune system

This project aims to evaluate the range of molecules that can stimulate vitamin B-reactive T cells in mammals and amphibians, and the degree..

Grants

Awarded by National Health and Medical Research Council (NHMRC)

Awarded by National Institute of Allergy and Infectious Diseases of the National Institutes of Health (NIH)

Awarded by Australian Research Council (ARC)

Awarded by National Health and Medical Research Council of Australia

Awarded by Australian Research Council

Funding Acknowledgements

The authors are supported by research grants from The National Health and Medical Research Council (NHMRC; 1113293, 1125493) and the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (NIH; R01AI148407). AJC is supported by a Future Fellowship (FT160100083) from the Australian Research Council (ARC). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH, NHMRC or ARC.

Keywords

3 Good Health and Well Being

Immunology

Life Sciences & Biomedicine