Journal article

Recommended Definitions of Aggressive Prostate Cancer for Etiologic Epidemiologic Research.

Lauren M Hurwitz, Ilir Agalliu, Demetrius Albanes, Kathryn Hughes Barry, Sonja I Berndt, Qiuyin Cai, Chu Chen, Iona Cheng, Jeanine M Genkinger, Graham G Giles, Jiaqi Huang, Corinne E Joshu, Tim J Key, Synnove Knutsen, Stella Koutros, Hilde Langseth, Sherly X Li, Robert J MacInnis, Sarah C Markt, Kathryn L Penney Show all

Journal of the National Cancer Institute | Published : 2021


BACKGROUND: In the era of widespread prostate-specific antigen testing, it is important to focus etiologic research on the outcome of aggressive prostate cancer, but studies have defined this outcome differently. We aimed to develop an evidence-based consensus definition of aggressive prostate cancer using clinical features at diagnosis for etiologic epidemiologic research. METHODS: Among prostate cancer cases diagnosed in 2007 in the National Cancer Institute's Surveillance, Epidemiology, and End Results-18 database with follow-up through 2017, we compared the performance of categorizations of aggressive prostate cancer in discriminating fatal prostate cancer within 10 years of diagnosis, p..

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