Journal article
White matter fiber microstructure is associated with prior hospitalizations rather than acute symptomatology in major depressive disorder
S Meinert, EJ Leehr, D Grotegerd, J Repple, K Förster, NR Winter, V Enneking, SM Fingas, H Lemke, L Waltemate, F Stein, K Brosch, S Schmitt, T Meller, A Linge, A Krug, I Nenadić, A Jansen, T Hahn, R Redlich Show all
Psychological Medicine | CAMBRIDGE UNIV PRESS | Published : 2022
Abstract
Background Eighty percent of all patients suffering from major depressive disorder (MDD) relapse at least once in their lifetime. Thus, understanding the neurobiological underpinnings of the course of MDD is of utmost importance. A detrimental course of illness in MDD was most consistently associated with superior longitudinal fasciculus (SLF) fiber integrity. As similar associations were, however, found between SLF fiber integrity and acute symptomatology, this study attempts to disentangle associations attributed to current depression from long-term course of illness. Methods A total of 531 patients suffering from acute (N = 250) or remitted (N = 281) MDD from the FOR2107-cohort were analy..
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Awarded by German Research Foundation (Deutsche Forschungsgemeinschaft, DFG)
Awarded by Interdisciplinary Center for Clinical Research (IZKF) of the medical faculty of Munster
Awarded by 'Innovative Medizinische Forschung' (IMF) of the medical faculty of Munster
Funding Acknowledgements
This work was supported by the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) (TK, grant numbers KI 588/14-1, KI 588/14-2, KI 588/15-1, KI 588/17-1), (UD, grant numbers DA 1151/5-1, DA 1151/5-2, DA 1151/6-1, SFB-TRR58, Projects C09 and Z02), (AK, grant numbers KR 3822/5-1, KR 3822/7-2), (IN, grant numbers NE 2254/1-2), (AJ, grant numbers JA 1890/7-1, JA 1890/7-2), (TH, grant number HA 7070/2-2); the Interdisciplinary Center for Clinical Research (IZKF) of the medical faculty of Munster (UD, grant number Dan3/012/17), (NO, grant number SEED 11/18); `Innovative Medizinische Forschung' (IMF) of the medical faculty of Munster (RR, grant numbers RE111604, RE111722), (JR, grant number RE221707), (EJL, grant number LE121703), and the Deanery of the Medical Faculty of the University of Munster.