Journal article

Greater male than female variability in regional brain structure across the lifespan

Lara M Wierenga, Gaelle E Doucet, Danai Dima, Ingrid Agartz, Moji Aghajani, Theophilus N Akudjedu, Anton Albajes-Eizagirre, Dag Alnaes, Kathryn Alpert, Ole A Andreassen, Alan Anticevic, Philip Asherson, Tobias Banaschewski, Nuria Bargallo, Sarah Baumeister, Ramona Baur-Streubel, Alessandro Bertolino, Aurora Bonvino, Dorret Boomsma, Stefan Borgwardt Show all

HUMAN BRAIN MAPPING | WILEY | Published : 2020


For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Consortium presents the largest-ever mega-analysis of sex differences in variability of brain structure, based on international data spanning nine decades of life. Subcortical volumes, cortical surface area and cortical thickness were assessed in MRI data of 16,683 healthy individuals 1-90 years old (47% females). We observed significant patterns of greater male than female between-subject variance for all subcortical volumetric measures, all cortical surface area measures, a..

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Awarded by Deutsche Forschungsgemeinschaft

Awarded by Deutsche Forschungsgesellschaft collaborative research center

Awarded by EU H2020

Awarded by European Community's Horizon 2020 Programme

Awarded by European Community's Seventh Framework Programme

Awarded by European Research Council

Awarded by German Research Foundation

Awarded by KNAW Academy Professor Award

Awarded by Miguel Servet Research Contract

Awarded by Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Awarded by NWO

Awarded by Netherlands Brain Foundation grant

Awarded by NIA

Awarded by NIH/NIMH

Awarded by NIHR Biomedical Research Centre for Mental Health

Awarded by NIHR senior investigator award

Awarded by NWO Brain & Cognition Excellence Program

Awarded by Research Council of Norway

Awarded by South London and Maudsley Trust

Awarded by South-Eastern Norway Regional Health Authority

Awarded by Generalitat de Catalunya

Awarded by UK Medical Research Council Grant

Awarded by Vici Innovation Program

Awarded by National Institute of Aging

Awarded by National Institute of General Medical Sciences

Awarded by Marato TV3 Foundation

Awarded by MRC

Funding Acknowledgements

BIG - Nijmegen 1.5T; Deutsche Forschungsgemeinschaft, Grant/Award Numbers: KFO 125, TRR 58/A1, TRR 58/A5, SFB-TRR 58/B01, SFB-TRR 58/B06; Deutsche Forschungsgesellschaft collaborative research center, Grant/Award Number: 636; EU H2020, Grant/Award Number: #667302; European Community's Horizon 2020 Programme, Grant/Award Numbers: 643051, 667302; European Community's Seventh Framework Programme, Grant/Award Numbers: 602805, 603016, 602450, 278948; European Research Council, Grant/Award Numbers: ERC-2010-StG-263234, ERC-230374; German Research Foundation, Grant/Award Number: KFO 125; KA Wallenberg Foundation; KNAW Academy Professor Award, Grant/Award Number: PAH/6635; Miguel Servet Research Contract, Grant/Award Number: CPII16/0020; Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Grant/Award Numbers: 51.02.061 to H.H., NWO 51.02.062 to D.B., NWO-NIH; Netherlands Brain Foundation grant, Grant/Award Number: 2010 (1)-50; NIA, Grant/Award Number: T32AG058507; NIH/NIMH, Grant/Award Numbers: 5T32MH073526, U54EB020403, U54 EB020403, R56 AG058; NIHR Biomedical Research Centre for Mental Health, Grant/Award Number: NIHR/MRC (14/23/17); NIHR senior investigator award, Grant/Award Number: NF-SI-0616-10040; NWO Brain & Cognition Excellence Program, Grant/Award Number: 433-09-229; Research Council of Norway, Grant/Award Numbers: #223273, #288083, #230345; South London and Maudsley Trust, Grant/Award Number: 064846; South-Eastern Norway Regional Health Authority, Grant/Award Numbers: #2017112, #2019069; the Generalitat de Catalunya, Grant/Award Number: 2017SGR01343; the German Research Foundation, Grant/Award Numbers: WA 1539/4-1, SCHN 1205/3-1; The Marato TV3 Foundation, Grant/Award Numbers: #091710, #091710; UK Medical Research Council Grant, Grant/Award Number: G03001896 to J Kuntsi; Vici Innovation Program, Grant/Award Numbers: 016-130-669, 91619115; National Institute of Aging, Grant/Award Number: R03AG064001; National Institute of General Medical Sciences, Grant/Award Number: P20GM130447