Journal article

Microstructural degeneration underlies executive dysfunction after stroke

Michele Veldsman, Emilio Werden, Natalia Egorova, Mohamed Salah Khlif, Amy Brodtmann

Scientific Reports | Cold Spring Harbor Laboratory | Published : 2020


ABSTRACTObjectiveExecutive dysfunction affects 40% of stroke patients and is associated with poor quality of life. Stroke severity and lesion volume rarely predict whether a patient will have executive dysfunction. Stroke typically occurs on a background of cerebrovascular burden, which impacts cognition and brain network structural integrity. We investigated whether measures of white matter microstructural integrity and cerebrovascular risk factors better explain executive dysfunction than markers of stroke severity.MethodsWe used structural equation modelling to examine multivariate relationships between cerebrovascular risk, white matter microstructural integrity (fractional anisotropy an..

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