Journal article

Impact microindentation in men with impaired fasting glucose and type 2 diabetes

Kara L Holloway-Kew, Amelia Betson, Pamela G Rufus-Membere, James Gaston, Adolfo Diez-Perez, Mark A Kotowicz, Julie A Pasco

Bone | ELSEVIER SCIENCE INC | Published : 2021


BACKGROUND: Individuals with type 2 diabetes (T2DM) are at increased fracture risk, with bone mineral density (BMD) measurements underestimating risk. Impact microindentation (IMI), a technique that measures bone microindentation distances, expressed as bone material strength index (BMSi), may improve fracture risk estimation in individuals with T2DM. This study describes the relationship between BMSi and glycaemia status in men and makes a comparison with bone measures from dual energy X-ray absorptiometry (DXA). MATERIAL AND METHODS: Participants were 340 men aged 33-96 yr from the Geelong Osteoporosis Study. Impaired fasting glucose (IFG) was defined using fasting plasma glucose (FPG) bet..

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University of Melbourne Researchers


Awarded by National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

The Geelong Osteoporosis Study was supported by grants from the National Health and Medical Research Council (NHMRC; projects 299831, 628582), Amgen-GSK OA-ANZBMS and Amgen Australia, but they played no role in the collection or interpretation of data.PGR was supported by Deakin University Postgraduate Industry Research Scholarship. KLH-K was supported by an Alfred Deakin Postdoctoral Research Fellowship. AD-P owns shares of Active Life Scientific, Inc., the manufacturer of the reference point indentation device.