Journal article

Skeletal Muscle Density and Cognitive Function: A Cross-Sectional Study in Men

Sophia X Sui, Lana J Williams, Kara L Holloway-Kew, Natalie K Hyde, Kara B Anderson, Monica C Tembo, Alex B Addinsall, Sarah Leach, Julie A Pasco



We aimed to investigate cross-sectional associations between skeletal muscle density, a proxy measure for fatty infiltration into muscle, and cognition. Contributions from body fat mass, systemic inflammation and lifestyle were explored, as these factors have been identified in both muscle and cognitive deterioration. For 281 men (60-95 year) from the Geelong Osteoporosis Study, radial and tibial muscle density were measured using peripheral quantitative computed tomography. Body fat and appendicular lean mass were measured using dual-energy X-ray absorptiometry. Cognitive function was assessed for psychomotor function (DET), visual identification/attention (IDN), visual learning (OCL) and w..

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University of Melbourne Researchers