Journal article

Skeletal Muscle Density and Cognitive Function: A Cross-Sectional Study in Men

Sophia X Sui, Lana J Williams, Kara L Holloway-Kew, Natalie K Hyde, Kara B Anderson, Monica C Tembo, Alex B Addinsall, Sarah Leach, Julie A Pasco



We aimed to investigate cross-sectional associations between skeletal muscle density, a proxy measure for fatty infiltration into muscle, and cognition. Contributions from body fat mass, systemic inflammation and lifestyle were explored, as these factors have been identified in both muscle and cognitive deterioration. For 281 men (60-95 year) from the Geelong Osteoporosis Study, radial and tibial muscle density were measured using peripheral quantitative computed tomography. Body fat and appendicular lean mass were measured using dual-energy X-ray absorptiometry. Cognitive function was assessed for psychomotor function (DET), visual identification/attention (IDN), visual learning (OCL) and w..

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University of Melbourne Researchers


Awarded by National Health and Medical Research Council (NHMRC) Australia

Funding Acknowledgements

The Geelong Osteoporosis Study was funded by the National Health and Medical Research Council (NHMRC) Australia (projects 251638, 628582). The funding organisations played no role in the design or conduct of the study, in the collection, management, analysis and interpretation of the data, nor in the preparation, review and approval of the manuscript.