Journal article

Associations Between Limbic System White Matter Structure and Socio-Emotional Functioning in Children with ADHD plus ASD

Kate Stephens, Timothy J Silk, Vicki Anderson, Philip Hazell, Peter G Enticott, Emma Sciberras

Journal of Autism and Developmental Disorders | SPRINGER/PLENUM PUBLISHERS | Published : 2020


Children with attention deficit/hyperactivity disorder (ADHD) combined with autism spectrum disorder (ASD) symptoms (ADHD + ASD) have poorer social and emotional functioning than those with ADHD alone. However, no studies have specifically examined the associations between ASD symptoms, measures of social and emotional functioning and limbic system white matter microstructure. Tractography on the cingulum, uncinate fasciculus and fornix were performed for 151 children with (N = 78) and without (N = 73) ADHD. Participants in the ADHD group who scored 11 or above on the Social Communication Questionnaire were classified as the ADHD + ASD group (N = 16). Significant differences in mean cingulum..

View full abstract


Awarded by Australian National Health and Medical Research Council (NHMRC)

Awarded by NHMRC

Funding Acknowledgements

This research was supported by Project Grants (1008522, 1065895) from the Australian National Health and Medical Research Council (NHMRC). ES is funded by an NHMRC Career Development Fellowship (1110688) and a veski Inspiring Women's Fellowship. This research was supported by the Victorian Government's Operation Infrastructure Support Program to the Murdoch Children's Research Institute.