Journal article

Symptom Remission and Brain Cortical Networks at First Clinical Presentation of Psychosis: The OPTiMiSE Study

Paola Dazzan, Andrew J Lawrence, Antje ATS Reinders, Alice Egerton, Neeltje EM van Haren, Kate Merritt, Gareth J Barker, Rocio Perez-Iglesias, Kyra-Verena Sendt, Arsime Demjaha, Kie W Nam, Iris E Sommer, Christos Pantelis, W Wolfgang Fleischhacker, Inge Winter van Rossum, Silvana Galderisi, Armida Mucci, Richard Drake, Shon Lewis, Mark Weiser Show all



Individuals with psychoses have brain alterations, particularly in frontal and temporal cortices, that may be particularly prominent, already at illness onset, in those more likely to have poorer symptom remission following treatment with the first antipsychotic. The identification of strong neuroanatomical markers of symptom remission could thus facilitate stratification and individualized treatment of patients with schizophrenia. We used magnetic resonance imaging at baseline to examine brain regional and network correlates of subsequent symptomatic remission in 167 medication-naïve or minimally treated patients with first-episode schizophrenia, schizophreniform disorder, or schizoaffectiv..

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University of Melbourne Researchers


Awarded by European Commission within the 7th Program

Funding Acknowledgements

This work was supported by a grant from the European Commission within the 7th Program (HEALTH-F2-2010-242114).