Associations between early life stress and anterior pituitary gland volume development during late childhood
Paige Farrow, Julian G Simmons, Elena Pozzi, Carmela Diaz-Arteche, Sally Richmond, Katherine Bray, Orli Schwartz, Sarah Whittle
Psychoneuroendocrinology | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2020
Early Life Stress (ELS) is thought to influence Hypothalamic-Pituitary-Adrenal-Axis (HPAA) functioning, contributing to an increased risk for psychopathology through dysregulation of biological stress responses. Research exploring relationships between ELS and HPAA functioning has largely focused on its key hormonal output, cortisol. However, findings have been inconsistent, potentially due to cortisol's distinctive diurnal patterns and dynamic nature complicating its accurate measurement. Thus, this study explored the link between ELS and a more stable, structural component of the HPAA, specifically, anterior pituitary gland volume (PGV) in a community sample of children (N = 129, 68 female..View full abstract
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Awarded by Australian Research Council
Awarded by National Health and Medical Research Council(NHMRC) Career Development Fellowship
This research was supported by the Australian Research Council (Discovery Grant ID DP130103551). Dr. Whittle is supported by a National Health and Medical Research Council(NHMRC) Career Development Fellowship (ID: 1125504).