Associations between vascular risk factors and subsequent Alzheimer's disease in older adults
Hyewon Lee, Kiwon Kim, Yeong Chan Lee, Soyeon Kim, Hong-Hee Won, Tae Yang Yu, Eun-Mi Lee, Jae Myeong Kang, Matthew Lewis, Doh Kwan Kim, Woojae Myung
ALZHEIMERS RESEARCH & THERAPY | BMC | Published : 2020
BACKGROUND: The clinical guidelines related to the primary prevention of Alzheimer's disease (AD) have focused on the management of vascular risk factors. However, the link between vascular risk factors and AD in older adults remains unclear. This study aimed to determine the association between vascular risk factors and subsequent AD in 178,586 older adults (age ≥ 65 years). METHODS: Participants were recruited from 2009 through 2010 and followed up for 6 years. We assessed various vascular risk factors (total cholesterol [TC], low-density lipoprotein cholesterol [LDL-C], high-density lipoprotein cholesterol [HDL-C], triglycerides [TG], fasting glucose [FG], systolic blood pressure [SBP], d..View full abstract
Awarded by National Research Foundation of Korea (NRF) - Ministry of Science and ICT (Information and Communication Technologies), South Korea
This work was supported by the National Research Foundation of Korea (NRF) Grant funded by the Ministry of Science and ICT (Information and Communication Technologies), South Korea [grant number NRF-2018R1C1B6001708; W Myung], and by the Soonchunhyang University Research Fund [H Lee]. The funding source was not involved in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.