Journal article

Excess cerebral oxygen delivery follows return of spontaneous circulation in near-term asphyxiated lambs

Shiraz Badurdeen, Andrew W Gill, Martin Kluckow, Calum T Roberts, Robert Galinsky, Sarah Klink, Suzanne L Miller, Peter G Davis, Georg M Schmolzer, Stuart B Hooper, Graeme R Polglase

Scientific Reports | NATURE RESEARCH | Published : 2020

Abstract

Hypoxic-ischaemia renders the neonatal brain susceptible to early secondary injury from oxidative stress and impaired autoregulation. We aimed to describe cerebral oxygen kinetics and haemodynamics immediately following return of spontaneous circulation (ROSC) and evaluate non-invasive parameters to facilitate bedside monitoring. Near-term sheep fetuses [139 ± 2 (SD) days gestation, n = 16] were instrumented to measure carotid artery (CA) flow, pressure, right brachial arterial and jugular venous saturation (SaO2 and SvO2, respectively). Cerebral oxygenation (crSO2) was measured using near-infrared spectroscopy (NIRS). Following induction of severe asphyxia, lambs received cardiopulmonary re..

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Grants

Awarded by National Health and Medical Research Council (NHMRC)


Funding Acknowledgements

The authors would like to thank Dr Kelly Crossley, Karyn Rodgers and Alison Moxham for their technical support. This work was supported by a National Health and Medical Research Council (NH&MRC) Project Grant (APP1158494), Fellowships (SM: APP1136216, PD: 1157782, SH: APP545921, GP: 1105526), a National Heart Foundation of Australia Future Leader Fellowship (GP), an Australian Government Research Training Program Scholarship (SB) and the Victorian Government's Operational Infrastructure Support Program.