A Novel Model to Estimate Key Obstructive Sleep Apnea Endotypes from Standard Polysomnography and Clinical Data and Their Contribution to Obstructive Sleep Apnea Severity
Ritaban Dutta, Gary Delaney, Barbara Toson, Amy S Jordan, David P White, Andrew Wellman, Danny J Eckert
ANNALS OF THE AMERICAN THORACIC SOCIETY | AMER THORACIC SOC | Published : 2021
Rationale: There are at least four key pathophysiological endotypes that contribute to obstructive sleep apnea (OSA) pathophysiology. These include 1) upper-airway collapsibility (Pcrit); 2) arousal threshold; 3) loop gain; and 4) pharyngeal muscle responsiveness. However, an easily interpretable model to examine the different ways and the extent to which these OSA endotypes contribute to conventional polysomnography-defined OSA severity (i.e., the apnea-hypopnea index) has not been investigated. In addition, clinically deployable approaches to estimate OSA endotypes to advance knowledge on OSA pathogenesis and targeted therapy at scale are not currently available.Objectives: Develop an inte..View full abstract
Awarded by National Health and Medical Research Council of Australia Senior Research Fellowship
Supported by a Collaborative Research Centre Consortium Grant between the Australian Government, Academia, and Industry (industry partner: Oventus Medical). D.J.E. is supported by a National Health and Medical Research Council of Australia Senior Research Fellowship (1116942).