Inhibition of Radiation and Temozolomide-Induced Glioblastoma Invadopodia Activity Using Ion Channel Drugs
Marija Dinevska, Natalia Gazibegovic, Andrew P Morokoff, Andrew H Kaye, Katharine J Drummond, Theo Mantamadiotis, Stanley S Stylli
Cancers | MDPI | Published : 2020
Glioblastoma (GBM) is the most prevalent and malignant type of primary brain cancer. The rapid invasion and dissemination of tumor cells into the surrounding normal brain is a major driver of tumor recurrence, and long-term survival of GBM patients is extremely rare. Actin-rich cell membrane protrusions known as invadopodia can facilitate the highly invasive properties of GBM cells. Ion channels have been proposed to contribute to a pro-invasive phenotype in cancer cells and may also be involved in the invadopodia activity of GBM cells. GBM cell cytotoxicity screening of several ion channel drugs identified three drugs with potent cell killing efficacy: flunarizine dihydrochloride, econazole..View full abstract
Awarded by Perpetual IMPACT Philanthropy Grant
This work was supported by the following funding sources: Perpetual IMPACT Philanthropy Grant IPAP2017/0766 and The Royal Melbourne Hospital Neuroscience Foundation.