Journal article

Impact of histological Oral Tongue Cancer margins on locoregional recurrence: A multi-centre retrospective analysis

James Daniell, Cristian Udovicich, David Rowe, Lachlan McDowell, Domenic Vital, Mathias Bressel, Matthew JR Magarey, Tim A Iseli, Tim Wong, Ernest Lekgabe, Karda Cavanagh, Tsien Fua, Danny Rischin, David Wiesenfeld

Oral Oncology | ELSEVIER | Published : 2020

Abstract

OBJECTIVES: To assess the effect of the histological margins (HM) upon locoregional failure (LRF) and overall survival (OS) for oral tongue squamous cell carcinoma (OTSCC). MATERIALS AND METHODS: We undertook a retrospective review of 258 patients, across two institutions, treated for OTSCC between 2007 and 2016. A Cox-proportional hazards model was used to compare the relative hazard ratio of HM to the accepted standard of 5 mm margins for LRF and OS. RESULTS: The median follow up period was 4.8 years. The 5 year OS and freedom from LRF were 69% and 75% respectively. The Cox-proportional hazards model adjusted for age, DOI and LVI showed increasing risk of mortality and LRF with decreasing ..

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