Modeling the potential of wAu-Wolbachia strain invasion in mosquitoes to control Aedes-borne arboviral infections
Samson T Ogunlade, Adeshina I Adekunle, Michael T Meehan, Diana P Rojas, Emma S McBryde
Scientific Reports | NATURE RESEARCH | Published : 2020
Arboviral infections such as dengue, Zika and chikungunya are fast spreading diseases that pose significant health problems globally. In order to control these infections, an intracellular bacterium called Wolbachia has been introduced into wild-type mosquito populations in the hopes of replacing the vector transmitting agent, Aedes aegypti with one that is incapable of transmission. In this study, we developed a Wolbachia transmission model for the novel wAu strain which possesses several favourable traits (e.g., enhanced viral blockage and maintenance at higher temperature) but not cyctoplasmic incompatibility (CI)-when a Wolbachia-infected male mosquito mates with an uninfected female mos..View full abstract
The first author was funded by the College of Medicine and Dentistry at James Cook University, Australia PhD programme.