The interaction of the circadian and immune system: Desynchrony as a pathological outcome to traumatic brain injury.
GR Yamakawa, RD Brady, M Sun, SJ McDonald, SR Shultz, R Mychasiuk
Neurobiology of Sleep and Circadian Rhythms | Elsevier BV | Published : 2020
Traumatic brain injury (TBI) is a complex and costly worldwide phenomenon that can lead to many negative health outcomes including disrupted circadian function. There is a bidirectional relationship between the immune system and the circadian system, with mammalian coordination of physiological activities being controlled by the primary circadian pacemaker in the suprachiasmatic nucleus (SCN) of the hypothalamus. The SCN receives light information from the external environment and in turn synchronizes rhythms throughout the brain and body. The SCN is capable of endogenous self-sustained oscillatory activity through an intricate clock gene negative feedback loop. Following TBI, the response o..View full abstract