An unconventional view of COVID-19 T cell immunity

Hui-Fern Koay; Thomas S Fulford; Dale I Godfrey

Journal article

An unconventional view of COVID-19 T cell immunity

Hui-Fern Koay, Thomas S Fulford, Dale I Godfrey

Journal of Experimental Medicine | ROCKEFELLER UNIV PRESS | Published : 2020

DOI: 10.1084/jem.20201727

Download PDF

Abstract

In this issue of JEM, Jouan et al. (https://doi.org/10.1084/jem.20200872) report the activation and skewed function of unconventional T cells in severe COVID-19 patients. This may reflect a role in COVID-19 immunity or pathogenesis and potentially identifies new therapeutic targets for this disease.

University of Melbourne Researchers

Dale Godfrey Author Microbiology and Immunology

Fern Koay Author Microbiology and Immunology

Tom Fulford Author Microbiology and Immunology

Related Projects (4)

UNCONVENTIONAL T CELLS IN HEALTH AND DISEASE

The human immune system comprises many different types of cells that can detect foreign molecules. My research will lead the way to understa..

CHARACTERISATION AND DEVELOPMENT OF MAIT CELLS

ANTIGEN PRESENTATION, RECOGNITION AND THE IMMUNE RESPONSE

This program focuses on understanding the development of immunity during infection or inflammatory diseases using a broad array of technique..

DEVELOPMENT AND SELECTION OF MAIT CELLS

MAIT cells are a recently discovered type of lymphocyte that plays a unique and important role in the immune system. However, these cells va..

Grants

Awarded by National Health and Medical Research Council of Australia

Awarded by National Health and Medical Research Council Early Career Fellowship

Awarded by National Health and Medical Research Council Senior Principal Research Fellowship

Awarded by Australian Research Council

Funding Acknowledgements

This work was supported by the National Health and Medical Research Council of Australia (1113293 and 1140126 to D.I. Godfrey). H-F. Koay is supported by an National Health and Medical Research Council Early Career Fellowship (1160333); D.I. Godfrey is supported by National Health and Medical Research Council Senior Principal Research Fellowship (1117766). D.I. Godfrey and H-F. Koay are also supported by the Australian Research Council (CE140100011). The figure is created partially with BioRender.com.