Journal article

Cancer Plasticity: The Role of mRNA Translation

Laura J Lee, David Papadopoli, Michael Jewer, Sonia del Rincon, Ivan Topisirovic, Mitchell G Lawrence, Lynne-Marie Postovit

TRENDS IN CANCER | CELL PRESS | Published : 2021

Abstract

Tumor progression is associated with dedifferentiated histopathologies concomitant with cancer cell survival within a changing, and often hostile, tumor microenvironment. These processes are enabled by cellular plasticity, whereby intracellular cues and extracellular signals are integrated to enable rapid shifts in cancer cell phenotypes. Cancer cell plasticity, at least in part, fuels tumor heterogeneity and facilitates metastasis and drug resistance. Protein synthesis is frequently dysregulated in cancer, and emerging data suggest that translational reprograming collaborates with epigenetic and metabolic programs to effectuate phenotypic plasticity of neoplasia. Herein, we discuss the pote..

View full abstract

Grants

Awarded by National Health and Medical Research Council, Australia


Awarded by Victorian Government through the Victorian Cancer Agency


Awarded by Canadian Institutes for Health Research (CIHR)


Awarded by CIHR Postdoctoral Fellowship


Awarded by CIHR Doctoral Research Award


Awarded by CIHR


Awarded by National Institutes of Health


Awarded by Joint Canada-Israel Health Research Program


Funding Acknowledgements

M.G.L received funding from the National Health and Medical Research Council, Australia, (project grant 1156570) and the Victorian Government acting through the Victorian Cancer Agency (fellowship MCRF18017). S.D.R. is funded by the Canadian Institutes for Health Research (CIHR; grant PJT-162260). D.P. is supported by a CIHR Postdoctoral Fellowship (MFE-171312), and L.J.L is supported by a CIHR Doctoral Research Award (GSD-158587). I.T. is a Senior Scholar of the Fonds de Recherche du Quebec-Sante and his laboratory is supported in part by CIHR (MOP-363027), National Institutes of Health (R01 CA 20202101-A1), and Joint Canada-Israel Health Research Program (108589-001). This work was supported by the CIHR (PLS 9538 and PLS 95381), the Alberta Cancer Foundation, the Women and Children's Health Research Institute (WCHRI), and Alberta Innovates Health Solutions (AIHS) through grants awarded to L.M.P. L.M.P. was the recipient of the Sawin-Baldwin Chair in Ovarian Cancer, the Dr. Anthony Noujaim Legacy Oncology Chair, and the AIHS Translational Health Chair in Cancer.