Does cortical brain morphology act as a mediator between childhood trauma and transition to psychosis in young individuals at ultra-high risk?
Marta Rapado-Castro, Sarah Whittle, Christos Pantelis, Andrew Thompson, Barnaby Nelson, Eleni P Ganella, Ashleigh Lin, Renate LEP Reniers, Patrick D McGorry, Alison R Yung, Stephen J Wood, Cali F Bartholomeusz
Schizophrenia Research | Published : 2020
BACKGROUND: Childhood trauma, particularly sexual abuse, has been associated with transition to psychosis in individuals at "ultra-high risk" (UHR). This study investigated whether the effects of various forms of childhood trauma on transition to psychosis are mediated by cortical thickness and surface area abnormalities. METHODS: This prospective study used data from 62 UHR individuals from a previous (PACE 400) cohort study. At follow-up, 24 individuals had transitioned to psychosis (UHR-T) and 38 individuals had not transitioned (UHR-NT). Student-t/Mann-Whitney-U tests were performed to assess morphological differences in childhood trauma (low/high) and transition. Mediation analyses were..View full abstract