Journal article

Large-Scale Evidence for an Association Between Peripheral Inflammation and White Matter Free Water in Schizophrenia and Healthy Individuals

Maria A Di Biase, Andrew Zalesky, Suheyla Cetin-Karayumak, Yogesh Rathi, Jinglei Lv, Danny Boerrigter, Hayley North, Paul Tooney, Christos Pantelis, Ofer Pasternak, Cynthia Shannon Weickert, Vanessa L Cropley

Schizophrenia Bulletin | Oxford University Press (OUP) | Published : 2021

Abstract

INTRODUCTION: Clarifying the role of neuroinflammation in schizophrenia is subject to its detection in the living brain. Free-water (FW) imaging is an in vivo diffusion-weighted magnetic resonance imaging (dMRI) technique that measures water molecules freely diffusing in the brain and is hypothesized to detect inflammatory processes. Here, we aimed to establish a link between peripheral markers of inflammation and FW in brain white matter. METHODS: All data were obtained from the Australian Schizophrenia Research Bank (ASRB) across 5 Australian states and territories. We first tested for the presence of peripheral cytokine deregulation in schizophrenia, using a large sample (N = 1143) comp..

View full abstract

Grants

Awarded by National Health and Medical Research Council (NHMRC)


Awarded by NHMRC


Awarded by National Institute of Mental Health


Funding Acknowledgements

This study was supported by National Health and Medical Research Council (NHMRC) Investigator grants (1175754 to M.A.D. and 1177370 to V.L.C.), NHMRC Senior Research Fellowship (1136649 to A.Z.), NMHRC Senior Principal Research Fellowship (1105825 to C.P. and 1117079 to C.S.W.), National Institute of Mental Health (R01MH108574 to O.P.) and the NSW Ministry of Health, Office of Health and Medical Research (C.S.W.).