Journal article

Skin autofluorescence in people with type 1 diabetes and people without diabetes: An eight-decade cross-sectional study with evidence of accelerated aging and associations with complications

AS Januszewski, D Xu, YH Cho, PZ Benitez-Aguirre, DN O'Neal, ME Craig, KC Donaghue, AJ Jenkins

Diabetic Medicine | WILEY | Published : 2020

Abstract

AIM: To measure skin autofluorescence in youth (<18 y.o.) and adults (≥18 y.o.) and to assess its relationship with type 1 diabetes, chronic complications and smoking. METHODS: In a cross-sectional study (n = 383) skin autofluorescence was measured in 269 people with type 1 diabetes (67 with vascular complications) and 114 people without diabetes, covering eight decades of age. Associations of skin autofluorescence with demographics and traditional risk factors were assessed. RESULTS: Skin autofluorescence increased with age in people with diabetes: for those with complications it increased by a mean ± se of 0.029 ± 0.003 arbitrary units per year (r = 0.76) and, for those without complicatio..

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Grants

Funding Acknowledgements

A.J.J. was supported by a National Health and Medical Research Council Practitioner Fellowship and was a Sydney Medical School Foundation Fellow. D.X. was supported by a NHMRC Clinical Trials Centre Scholarship.