Journal article

Small airway remodeling in a sheep model of bleomycin-induced pulmonary fibrosis

Habtamu B Derseh, Sasika N Vithana Dewage, Udari E Perera, Emmanuel Koumoundouros, Charles N Pagel, Louise Organ, Ken J Snibson

Experimental Lung Research | TAYLOR & FRANCIS INC | Published : 2020


Background: Although IPF is described traditionally as a disease affecting lung parenchyma, there is renewed interest in the alterations in the structure and function of the small airways in both IPF patients, and animal models of pulmonary fibrosis. Small airway remodeling may contribute to the pathophysiology of pulmonary fibrosis. Given the dearth of knowledge of small airway changes in pulmonary fibrosis, this study aims to assess the structural remodeling, as well as functional changes associated with bleomycin-injured small airways in a sheep model of pulmonary fibrosis. Materials and Methods: Two separate lung segments in ten sheep received two challenges of either 3 IU bleomycin, or ..

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