Journal article

Preventing the development of severe COVID-19 by modifying immunothrombosis

Gerwyn Morris, Chiara C Bortolasci, Basant K Puri, Lisa Olive, Wolfgang Marx, Adrienne O'Neil, Eugene Athan, Andre Carvalho, Michael Maes, Ken Walder, Michael Berk

Life Sciences | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2021

Abstract

BACKGROUND: COVID-19-associated acute respiratory distress syndrome (ARDS) is associated with significant morbidity and high levels of mortality. This paper describes the processes involved in the pathophysiology of COVID-19 from the initial infection and subsequent destruction of type II alveolar epithelial cells by SARS-CoV-2 and culminating in the development of ARDS. MAIN BODY: The activation of alveolar cells and alveolar macrophages leads to the release of large quantities of proinflammatory cytokines and chemokines and their translocation into the pulmonary vasculature. The presence of these inflammatory mediators in the vascular compartment leads to the activation of vascular endothe..

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