Journal article

Microstructural degeneration and cerebrovascular risk burden underlying executive dysfunction after stroke

Michele Veldsman, Emilio Werden, Natalia Egorova, Mohamed Salah Khlif, Amy Brodtmann



Executive dysfunction affects 40% of stroke patients, but is poorly predicted by characteristics of the stroke itself. Stroke typically occurs on a background of cerebrovascular burden, which impacts cognition and brain network structural integrity. We used structural equation modelling to investigate whether measures of white matter microstructural integrity (fractional anisotropy and mean diffusivity) and cerebrovascular risk factors better explain executive dysfunction than markers of stroke severity. 126 stroke patients (mean age 68.4 years) were scanned three months post-stroke and compared to 40 age- and sex-matched control participants on neuropsychological measures of executive funct..

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Awarded by National Health and Medical Research Council

Funding Acknowledgements

We would like to thank our patients and their carers for their time taking part in the experiment over a number of years. This work was supported by the National Health and Medical Research Council project grant number APP1020526, the Brain Foundation, Wicking Trust, Collie Trust, and Sidney and Fiona Myer Family Foundation.