Journal article

Characterising the immune microenvironment in liposarcoma, its impact on prognosis and the impact of radiotherapy

Hayden Snow, Catherine Mitchell, Shona Hendry, Madeleine McKinley, David Byrne, Sam Ngan, Sarat Chander, Julie Chu, Jayesh Desai, Susie Bae, Michael Henderson, Peter Choong, David Gyorki

JOURNAL OF SURGICAL ONCOLOGY | WILEY | Published : 2020

Abstract

BACKGROUND AND OBJECTIVES: Limited literature exists examining the immune microenvironment in liposarcoma, particularly with regard to the impact of radiotherapy. A major problem is the lack of scoring system for the tumour-infiltrating lymphocytes (TILs) in sarcoma. This study aims to describe the immune environment pre- and postradiotherapy and identify the optimal immune infiltrate scoring system for sarcoma. METHODS: Thirty-nine paired tissue samples (pre- and postradiotherapy) from patients with liposarcoma were scored by two pathologists for TILs using pre-existing systems (for breast cancer and melanoma) and compared for interobserver reliability. Immunohistochemical staining was perf..

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