Journal article

A comparative whole genome analysis ofHelicobacter pylorifrom a human dense South Asian setting

Shamsul Qumar, Hoa Nguyen Trang, Shamsun Nahar, Nishat Sarker, Stephen Baker, Dieter Bulach, Niyaz Ahmed, Motiur Rahman

Helicobacter (Oxford) | WILEY | Published : 2020

Abstract

Helicobacter pylori, a Gram-negative bacterium, is associated with a wide range of gastric diseases such as gastritis, duodenal ulcer, and gastric cancer. The prevalence of H pylori and risk of disease vary in different parts of the world based on the prevailing bacterial lineage. Here, we present a contextual and comparative genomics analysis of 20 clinical isolates of H pylori from patients in Bangladesh. Despite a uniform host ethnicity (Bengali), isolates were classified as being part of the HpAsia2 (50%) or HpEurope (50%) population. Out of twenty isolates, eighteen isolates were cagA positive, with two HpEurope isolates being cagA negative, three EPIYA motif patterns (AB, AB-C, and ABC..

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University of Melbourne Researchers