Influenza A virus causes maternal and fetal pathology via innate and adaptive vascular inflammation in mice.
Stella Liong, Osezua Oseghale, Eunice E To, Kurt Brassington, Jonathan R Erlich, Raymond Luong, Felicia Liong, Robert Brooks, Cara Martin, Sharon O'Toole, Antony Vinh, Luke AJ O'Neill, Steven Bozinovski, Ross Vlahos, Paris C Papagianis, John J O'Leary, Doug A Brooks, Stavros Selemidis
Proc Natl Acad Sci U S A | Published : 2020
Influenza A virus (IAV) infection during pregnancy causes severe maternal and perinatal complications, despite a lack of vertical transmission of IAV across the placenta. Here, we demonstrate a significant alteration in the maternal vascular landscape that underpins the maternal and downstream fetal pathology to IAV infection in mice. In IAV infection of nonpregnant mice, the local lung inflammatory response was contained to the lungs and was self-resolving, whereas in pregnant mice, virus dissemination to major maternal blood vessels, including the aorta, resulted in a peripheral "vascular storm," with elevated proinflammatory and antiviral mediators and the influx of Ly6Clow and Ly6Chigh m..View full abstract
Awarded by Department of Health | National Health and Medical Research Council
Awarded by Australian Research Council