Journal article

Serum Protein Biomarker Findings Reflective of Oxidative Stress and Vascular Abnormalities in Male, but Not Female, Collision Sport Athletes

Brendan P Major, Stuart J McDonald, William T O'Brien, Georgia F Symons, Meaghan Clough, Daniel Costello, Mujun Sun, Rhys D Brady, Jesse Mccullough, Roxanne Aniceto, I-Hsuan Lin, Meng Law, Richelle Mychasiuk, Terence J O'Brien, Denes V Agoston, Sandy R Shultz

FRONTIERS IN NEUROLOGY | FRONTIERS MEDIA SA | Published : 2020

Abstract

Studies have indicated that concussive and sub-concussive brain injuries that are frequent during collision sports may lead to long-term neurological abnormalities, however there is a knowledge gap on how biological sex modifies outcomes. Blood-based biomarkers can help to identify the molecular pathology induced by brain injuries and to better understand how biological sex affects the molecular changes. We therefore analyzed serum protein biomarkers in male (n = 50) and female (n = 33) amateur Australian rules footballers (i.e., Australia's most participated collision sport), both with a history of concussion (HoC) and without a history of concussion (NoHoC). These profiles were compared to..

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