Serum Protein Biomarker Findings Reflective of Oxidative Stress and Vascular Abnormalities in Male, but Not Female, Collision Sport Athletes
Brendan P Major, Stuart J McDonald, William T O'Brien, Georgia F Symons, Meaghan Clough, Daniel Costello, Mujun Sun, Rhys D Brady, Jesse Mccullough, Roxanne Aniceto, I-Hsuan Lin, Meng Law, Richelle Mychasiuk, Terence J O'Brien, Denes V Agoston, Sandy R Shultz
FRONTIERS IN NEUROLOGY | FRONTIERS MEDIA SA | Published : 2020
Studies have indicated that concussive and sub-concussive brain injuries that are frequent during collision sports may lead to long-term neurological abnormalities, however there is a knowledge gap on how biological sex modifies outcomes. Blood-based biomarkers can help to identify the molecular pathology induced by brain injuries and to better understand how biological sex affects the molecular changes. We therefore analyzed serum protein biomarkers in male (n = 50) and female (n = 33) amateur Australian rules footballers (i.e., Australia's most participated collision sport), both with a history of concussion (HoC) and without a history of concussion (NoHoC). These profiles were compared to..View full abstract
This research was funded by grants and fellowships from the National Health and Medical Research Council of Australia to SS.