Journal article

Ablation of C3 modulates macrophage reactivity in the outer retina during photo-oxidative damage

Haihan Jiao, Jan M Provis, Riccardo Natoli, Matt Rutar

MOLECULAR VISION | MOLECULAR VISION | Published : 2020

Abstract

Purpose: Dysregulation of the complement cascade contributes to a variety of retinal dystrophies, including age-related macular degeneration (AMD). The central component of complement, C3, is expressed in abundance by macrophages in the outer retina, and its ablation suppresses photoreceptor death in experimental photo-oxidative damage. Whether this also influences macrophage reactivity in this model system, however, is unknown. We investigate the effect of C3 ablation on macrophage activity and phagocytosis by outer retinal macrophages during photo-oxidative damage. Methods: Age-matched C3 knockout (KO) mice and wild-type (WT) C57/Bl6 mice were subjected to photo-oxidative damage. Measureme..

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