Journal article

The immune phenotype of tongue squamous cell carcinoma predicts early relapse and poor prognosis

Giuseppe Troiano, Corrado Rubini, Lucrezia Togni, Vito Carlo Alberto Caponio, Khrystyna Zhurakivska, Andrea Santarelli, Nicola Cirillo, Lorenzo Lo Muzio, Marco Mascitti

CANCER MEDICINE | WILEY | Published : 2020

Abstract

BACKGROUND: In patients with squamous cell carcinoma of the oral tongue (OTSCC), current tumor node metastasis staging system fails to identify at-risk patients associated with early relapse and poor prognosis despite complete surgical resection. Given the importance of tumor-infiltrating lymphocytes (TILs) in the development of cancers, here we investigated the prognostic significance of the immune phenotype in OTSCC. METHODS: Hematoxylin-eosin stained sections of OTSCCs from 211 patients were evaluated. Cancers were classified as (a) immune-inflamed when TILs were found next to tumor cell nests; (b) immune-excluded when TILs were found in the stroma, outside the tumor; and (c) immune-deser..

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University of Melbourne Researchers