Journal article

MicroRNAs 363 and 149 are differentially expressed in the maternal circulation preceding a diagnosis of preeclampsia

Carole-Anne Whigham, Teresa M MacDonald, Susan P Walker, Richard Hiscock, Natalie J Hannan, Natasha Pritchard, Ping Cannon, Vi Nguyen Tuong, Manisha Miranda, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

SCIENTIFIC REPORTS | NATURE PORTFOLIO | Published : 2020

Abstract

Preeclampsia is a pregnancy complication associated with angiogenic dysbalance, maternal endothelial dysfunction and end-organ injury. A predictive test to identify those who will develop preeclampsia could substantially decrease morbidity and mortality. MicroRNAs (miRs) are small RNA molecules involved in post-transcriptional gene regulation. We screened for circulating miRs differentially expressed at 36 weeks' gestation in pregnancies before the development of preeclampsia. We used a case-control group (198 controls, 34 pre-preeclampsia diagnosis) selected from a prospective cohort (n = 2015) and performed a PCR-based microarray to measure the expression of 41 miRs. We found six circulati..

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Grants

Awarded by National Health and Medical Research Council (NHMRC of Australia)


Awarded by Harold Mitchell Foundation Health Fellowship by NHMRC Fellowships


Funding Acknowledgements

This work was supported by the National Health and Medical Research Council (NHMRC of Australia (#1065854), Australian Government Training Program Scholarship, and RANZCOG Taylor Hammond Scholarship to TM; the Norman Beischer Medical Research Foundation and The Harold Mitchell Foundation Health Fellowship to CW. S Tong (#1136418), T.J. Kaitu'u-Lino (#11359261) and N.J. Hannan (#1146128) were supported by NHMRC Fellowships. The funders had no role in study design, data collection, analysis, decision to publish or the preparation of the manuscript.